Estradiol Valerate


Estradiol Valerate is the major estrogen secreted by ovary. It synthesized in the graffian follicle, corpus luteum and placenta from cholesterol. Estradiol Valerate is rapidly oxidized in liver to estrone, which is hydroxylated to form estriol. All these three forms are found in blood. It is the most potent of the three. Secreted in menstruating women under the influence f FSH and concentration of Estradiol Valeratein blood increases during follicular phase. After ovulation corpus luteum continues to secrete estrogens till about 2 days before menstruation. You can easily buy Estradiol Valerate here at.



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10 to 14 days express shipping – or 3 to 4 weeks for regular shipping. | Medshop4u Online Pharmacy.

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You need to add Minimum 80$ Amount to your card | Medshop4u Online Pharmacy.

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Side effects

The common side effects reported with Estradiol Valerateare changes in vaginal bleeding pattern, spotting, dysmenorrhea, increase in size of uterine leiomyomata, vaginitis, change in amount of cervical secretion, changes in cervical ectropion, ovarian cancer, endometrial hyperplasia, endometrial cancer, tenderness, enlargement, pain, nipple discharge, galactorrhea, fibrocystic breast changes, nausea, vomiting, abdominal cramps and bloating.


Estradiol Valerateaccelerates prothrombin time and platelet aggregation time. Estrace causes a substantial increase in blood pressure. Estradiol Valeratetherapy may be associated with elevations of plasma triglycerides leading to pancreatitis and other complications. It should be used with caution in patients with impaired liver function and past history of cholestatic jaundice. Estrace can cause some fluid retention. Estrogens should be used with caution in individuals with severe hypocalcemia. Endometriosis may be exacerbated with administration of Estrace. It is contraindicated in women with asthma, diabetes mellitus, epilepsy, migraine or porphyria, systemic lupus erythematosus, and hepatic hemangiomas. The long-term use of Estradiol Valeratecan cause endometrial cancer, breast cancer, and ovarian cancer. Estrace should not be used during pregnancy. Administration of Estrace to nursing mothers decreases the quantity and quality of the milk. This should not be used in pediatric patients. Estradiol Valerate is contraindicated in abnormal genital bleeding, history of cancer of the breast, estrogen-dependent neoplasia, active deep vein thrombosis and pulmonary embolism.

How does Estradiol Valerate Work?

Estradiol Valerateis largely responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. Estradiol Valerateis rapidly oxidized in liver to estrone, which is hydroxylated to form estriol. Estrogens act through binding to nuclear receptors in estrogen-responsive tissues. Estrogens exercise feed back inhibition of FSH by direct action on pitituary as well as through hypothalamus.


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