The common side effects reported with Zetia are diarrhea, fatigue, influenza, sinusitis, upper respiratory tract infection, arthralgia and pain in extremity.

Zetia can be administered without regard of food. Ezetimibe can be combined with statins or with fenofibrate for incremental effect. It is advised to take Zetia at the same time as that of statin or fenofibrate. Ezetimibe should be administered 2 hours before or 4 hours after administering bile acid sequestrant. There is no need of dosage adjustment in patients with mild renal or hepatic impairment. Zetia is not used in patients with moderate to severe hepatic impairment. It is recommended to perform liver tests at regular intervals when Zetia is added to statin therapy. If you are a woman of childbearing age you are advised to use effective birth control method while using Zetia added to statin therapy. The combination of Zetia with statin is contraindicated in patients with active liver disease. Ezetimibe with statin should not be administered to pregnant women and in nursing mothers.

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