The common side effects reported with Letrozole are cataract, eye irritations, palpitations, cardiac failure, dysesthesia, arterial thrombosis, memory impairment, irritability, nervousness, increased urinary frequency, pyrexia, apetite increased, dryness of skin and mouth and disturbance of taste.

Letrozole can be taken without regard of food. The patients treated with Letrozole do not require replacement therapy with glucocorticoid or mineralocorticoid. The dosage of Femara need not be adjusted in elderly patients and in patients with mild to moderate renal or hepatic impairment. In severe hepatic dysfunction the dose of Letrozole should be reduced. It is advised to avod activities requiring alertness such as driving during treatment with Femara as it can cause fatigue and dizziness. It is also advised to monitor bone mass density in long-term therapy with Femara as it causes a loss in mineral content of bones. Letrozole is not safe in pregnant women. Femara is not recommended in nursing mothers and in pediatric patients. Letrozole is contraindicated in women with premenopausal endocrine status. To get the best results, it is advised to take Letrozole regularly at same time of day to maintain constant levels in blood.

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Letrozole is a potent and selective aromatase enzyme inhibitor. Letrozole inhibits the conversion of adrenal androgens to estrogen. Femara lowers the amount of estradiol and thus prevents the progression of breast cancer.