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The common side effects reported with Levonorgestrel are nausea, abdominal pain, fatigue, headache, heavy menstrual bleeding, dizziness, breast tenderness, vomiting and diarrhea.

It is advised to consult a doctor in case of vomiting within one hour of Levonorgestrel tablet intake. Plan B is not used in the termination of an existing pregnancy. Levonorgestrel cannot be used as a regular contraceptive method. It is advised to consult a doctor if menses delays more than one week. The patient should be informed about the chances of ectopic pregnancy. The discontinuation of Plan B results in full return of fertility. Plan B does not protect from AIDS and other sexually transmitted diseases. The intake of Levonorgestrel can cause carbohydrate intolerance. The effectiveness of Levonorgestrel is reduced by hepatic enzyme inducing drugs like anticonvulsants, rifampin, phenytoin, Carbamazepine and barbiturates. Levonorgestrel does not interact with broad spectrum antibiotics like penicillins and cephalosporins.