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The common side effectsreported with Paroxetine are nausea, somnolence, insomnia, agitation, nervousness, tremor, dry mouth, constipation, flatulence, asthenia, abnormal ejaculation, sweating, libido decreased, dizziness and impotence. Some of the rarer side effects reported during clinical trials are irregular heartbeats, chest pain, changes in the mood and buzzing or ringing in the ears.

It is advised toexercise caution when Paxil is administered with other drugs that may affect the serotonergic neurotransmitter systems such as triptans, Tramadol and other serotenergic drugs. Paroxetine when administered along with non-steroidal anti-inflammatory agents (NSAIDs) can cause increased risk of bleeding It is recommended that the total daily dose be reduced in patients with renal and hepatic impairment. It is advisable to consume the Paxil during pregnancy with caution and the dose of the drug should be gradually tapered by the last trimester of pregnancy. Avoid use of alcohol when you are taking Paxil. Patients should be advised to avoid involving in activities that require alertness.