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The common side effects reported with Lotrel are asthenia, fatigue, insomnia, nervousness, anxiety, tremor, decreased libido, flushing, hot flashes, rash, skin nodule, dermatitis, dry mouth, nausea, constipation, dyspepsia, hypokalemia, back pain, muscle cramps, polyuria and impotence.

Lotrel is not recommended in patients with severe renal impairment. The concomitant administration of Lotrel and potassium supplements or potassium sparing diuretics can increase the levels of potassium in the blood. In patients taking diuretic along with Lotrel, there is a chance of developing hypotension. Hence it is advisable to discontinue diuretic before Lotrel treatment or take additional salt supplements. The co-administration of lithium and Benazepril- Amlodipine should be followed by a continuous monitoring of serum lithium levels as it can lead to lithium toxicity. Lotrel should be administered with caution in patients with hepatic impairment. It is not advisable to consume the Lotrel during pregnancy as it can lead to fetal death. Lotrel is not recommended in nursing mothers and in pediatric patients. The initial dose of Lotrel should be low in elderly patients.