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The action of Aripiprazole is mediated through a combination of partial agonist activity at D2 and 5-HT1A receptors and antagonist activity at 5-HT2A receptors. The inhibition activity at adrenergic alpha1 receptors is responsible for the orthostatic hypotension shown by Aripiprazole.

The common side effects reported with Abilify are nausea, vomiting, constipation, headache, dizziness, akathisia, anxiety, insomnia, and restlessness, somnolence and extrapyramidal disorder.

Aripiprazole can be taken without regard of food. Abilify should not be administered in patients with dementia related psychosis. The dose of Abilify should be adjusted in patients with hepatic or renal impairment. The patient should be cautioned about the incidence of a syndrome of potentially irreversible, involuntary, dyskinetic movements known as tardive dyskinesia. Abilify can cause a potentially fatal symptom complex referred to as Neuroleptic Malignant Syndrome (NMS). Abilify can also cause diabetes mellitus and orthostatic hypotension in some patients. Abilify has the potential to impair judgment, thinking, or motor skills. It is advised to operate hazardous machinery and automobiles under the inflence of this drug as Aripiprazole impairs motor skills. Abilify should not be administered in pediatric patients below the age of 13. Aripiprazole is not recommended during pregnancy and lactation. The patient should be advised to avoid alcohol during the treatment with Abilify drug.

The recommended starting dose for Abilify in Schizophrenia is 10 mg/day or 15 mg/day administered once daily without regard to meals. The recommended dose of Abilify in pediatric patients (13-17years of age) is 10 mg/day. The recommended starting dose is 15 mg as monotherapy or as adjunctive therapy with lithium or valproate given once daily, without regard to meals in bipolar disorders. The dose can be increased to 30 mg/day based on clinical response. . The recommended dose of Abilify is 10 mg/day, as monotherapy or as adjunctive therapy with lithium or valproate in ppediatic patients (10-17years of age).