Colchicine is neither analgesic nor anti-inflammatory. Uric acid is a product of purine metabolism, which has low water solubility. When the level of uric acid is high in blood, it precipitates and gets deposited in joints, kidney and subcutaneous tissues. Colchicine does not inhibit synthesis or promote excretion of uric acid. An acute attack of gout is started by precipitation of urate crystals in synovial fluid. The inflammatory response is started and granulocyte phagocytoses urate crystals and releases a glycoprotein. Colchicine is a very effective drug and easily available. You can now buy Colchicine here


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How does Colchicine / Generic of Colcrys , Mitigar

The acute gout initiates an inflammatory response and releases a glycoprotein. The release of glycoprotein aggravates the inflammation by increasing lactic acid production from inflammatory cells and by releasing lysosomal enzymes. The increased lactic acid production decreases the local pH and cause more precipitation of urate crystals in the joint. The release of lysosomal enzymes causes joint destruction. Colcrys inhibits the synthesis of glycoprotein and subsequent events by binding to protein tubulin. Colcrys inhibits granulocyte migration into the inflamed joint.

Side effects of Colchicine / Generic of Colcrys ,

The common side effects reported with Colcrys are bone marrow depression, aplastic anemia, agranulocytosis, thrombocytopenia, peripheral neuritis, purpura, myopathy, loss of hair, reversible azoospermia, vomiting, diarrhea, nausea , dermatoses and hypersensitivity reactions.

Guidelines before using Colchicine / generic Colcr

Colcrys should be administered with caution along with acidifying and alkalinizing agents. The action of acidifying agents is inhibited by Colchicine and action of alkalinizing agents is potentiated by Colchicine. Colchicine and CNS depressants should not be administered together as Colcrys increases the sensitivity of CNS depressants. The response to sympathomimetic agents is enhanced by Colcrys. Colcrys should be administered with caution in elderly patients and in patients with gastrointestinal, renal, hepatic, cardiac, or hematological disorders. Colchicine should not be administered in pregnant women and in nursing mothers. If it is an absolute must to take Colcrys during pregnancy and lactation, it should be administered under the supervision of a medical practitioner.

What are the common dosages of Colchicine

The recommended starting dosage of Colcrys to relieve or abort an attack is 1 to 1.2 mg (two 0.5 mg granules or two 0.6 mg tablets). This dose may be followed by one unit of either granule or tablet preparation every hour, or two units every two hours, until pain is relieved.


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