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Seroquel acts by dopamine type 2 (D2) and serotonin type 2 (5HT2) antagonism.

The common side effects reported with Seroquel are flu syndrome, anorexia, palpitation, pharyngitis, rhinitis, cough increased, dyspnea, peripheral edema, sweating, leukopenia and urinary incontinence.

Quetiapine Fumarate should be administered in a lower dose in elderly patients, patients with hepatic impairment and debilitated patients. The maintenance dose of Seroquel should be increased when given along with enzyme inducers like phenytoin. Seroquel administration can cause hyperglycemia with ketoacidosis in diabetic patients. Quetiapine Fumarate can cause a potentially fatal symptom complex Neuroleptic Malignant Syndrome manifested as hyperpyrexia, muscle rigidity, altered mental status, and evidence of autonomic instability. The use of Quetiapine Fumarate can cause orthostatic hypotension in some patients. Seroquel is contraindicated in patients with cardiovascular disease. Seroquel medicine should not be prescribed to pregnant women and nursing mothers as it can pass in to breast milk.

The recommended starting dosage of Seroquel for depression is 50mg once daily at bedtime and this dose is increased to 300mg by fourth day in increments of 50mg. In the treatment of mania, Seroquel should be initiated in bid doses of 100 mg/day and increased up to 400mg/day in a period of 4 days. In schizophrenia, Seroquel should be administered with an initial dose of 25 mg bid and increased in increments of 25-50 mg bid or tid on the second and third day to a tolerated to a target dose range of 300 to 400mg daily by the fourth day, given bid or tid.