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The primary site of action of Baclofen is spinal cord where it depresses both polysynaptic and monosynaptic reflexes.

The common side effects reported with Lioresal are Confusion, headache, insomnia, euphoria, excitement, depression, hallucinations, paresthesia, muscle pain, tinnitus, slurred speech, coordination disorder, tremor, rigidity, dystonia, ataxia, blurred vision, nystagmus, strabismus, miosis, mydriasis, diplopia, dysarthria, epileptic seizure, hypotension, nausea, constipation, dry mouth, anorexia, taste disorder, abdominal pain, vomiting, diarrhea, urinary frequency enuresis, urinary retention, dysuria, impotence, inability to ejaculate, nocturia, hematuria, instances of rash, pruritus, ankle edema, excessive perspiration, weight gain and nasal congestion.

The use of Baclofen is not recommended in pediatric patients below the age of 12. The patients should be advised to avoid alcohol and CNS depressants while on Lioresal treatment as it can potentiate sedation. It is advised to avoid activities that require alertness and concentration like operating machinery and driving as Lioresal decreased alertness. The long-term use of Lioresal can cause the incidence of ovarian cysts. It is not advisable to consume the Lioresal during pregnancy and lactation. Baclofen should not be administered for the treatment of skeletal muscle spasm resulting from rheumatic disorders.

The recommended starting dosage of Lioresal is 5mg thrice daily for 3 days. The dose of Lioresal should be slowly titrated to a maximum dose of 80mg daily. The optimum dose of Lioresal is between 20-80mg and optimal dose is determined by individual titration.