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Zanaflex inhibits release of excitatory amino acids in spinal interneurones. Zanaflex facilitates inhibitor transmitter glycine. Tizanidine inhibits polysynaptic reflexes, reduces muscle tone and frequency of muscle spasms.

The common side effects reported with Zanaflex are dry Mouth, somnolence, asthenia, dizziness, UTI, constipation, liver function tests abnormal, vomiting, speech disorder, blurred vision, urinary frequency, flu symptom, dyskinesia, nervousness, pharyngitis and rhinitis.

Tizanidine ought to be utilized with alert in patients with renal deficiency. The accompanying utilization of Tizanidine and oral contraceptives ought to be kept away from. The portion of Zanaflex ought to be diminished in old patients. Tizanidine isn’t managed to pediatric patients. Zanaflex ought not be given to pregnant ladies. On the off chance that it is an outright should to take Zanaflex during pregnancy, it ought to be controlled under the management of a clinical expert. Zanaflex isn’t given to nursing moms as it can go in to bosom milk. Tizanidine ought not be utilized for long length in high portion as it can cause orthostatic hypotension. . The patient ought to be encouraged to keep away from exercises that require readiness and focus like working hardware and driving as Tizanidine causes sedation. Avoide liquor while on Tizanidine treatment.

The recommended dosage of 8 mg of tizanidine reduces muscle tone in patients with spasticity for a period of several hours.