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The common side effects reported with Prednisolone are sodium retention, fluid retention, congestive heart failure, hypokalemic alkalosis, hypertension, muscle weakness, steroid myopathy, loss of muscle mass, osteoporosis, vertebral compression, fractures, pathologic fracture of long bones,peptic ulcer, pancreatitis, abdominal distention, ulcerative esophagitis, impaired wound healing, thin fragile skin, facial erythema convulsions, increased intracranial pressure and menstrual irregularities.

There is an enhanced effect of Prednisolone in patients with hypothyroidism and cirrhosis. Pravachol should be used cautiously in patients with ocular herpes simplex as it can cause corneal perforation. Prednisolone should be given in the lowest possible doses and dose reduction should be done at a slow rate. Prednisolone should be used with caution in nonspecific ulcerative colitis. Pravachol drug is contraindicated in systemic fungal infections. The patient should be warned to avoid exposure to chickenpox or measles, as Prednisolone is an immunosuppressant.