The common side effects reported with using Imitrex Nasal Spray are irritation of nose and throat, a bad taste in the mouth, sensations of numbness, weakness, drowsiness and dizziness. Some patients have also reported atightness in the chest, jaw or neck. All these signs are mild in nature and does not reflect a resinous condition.

MAO inhibitors such as furazolidone, linezolid, phenelzine etc should not be used for at least 2 weeks before or after using Sumatriptan. Drugs falling in the class of SSRIs or SNRIs and triptans should not be co-administered with Imitrex. Sumatriptan nasal spray should be used with caution if you are diagnosed with or impaired hepatic or renal functions. Imitrex nasal spray should be used by pregnant women only if absolutely necessary. Nursing mothers should avoid breastfeeding for 12 hours after administering Imitrex Nasal Spray. Sumatriptan Nasal Spray is not recommended for use in pediatric patients.

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Sumatriptan is a selective agonist for vascular 5-hydroxytryptamine receptor subtype. It activates vascular 5-HT1 receptor which mediates constriction of the blood vessels. This constriction is believed to provide relief of migraine headaches.

The recommended dosage of Sumatriptan for the acute treatment of migraine in adults is single doses of 5, 10 and 20 mg into one nostril.The dose can be repeated after 2 hours if sufficient clinical response is not seen in patients. The maximum tolerated dose of Sumatriptan Nasal Spray is 40mg/day.