The common side effects reported with Sumig are burning sensation, numbness, palpitations, syncope, decreased blood pressure, increased blood pressure sinusitis, tinnitus, allergic rhinitis, upper respiratory inflammation, external otitis, hearing loss, nasal inflammation, sensitivity to noise, diarrhea, myalgia, photophobia, dyspnea, sweating and hypersensitivity.

The concomitant use of MAO inhibitors and Sumatriptan is not recommended. The dose of Sumig should be low in case the patient is suffering from hepatic or renal impairment. The co-administration of Selective Serotonin Reuptake Inhibitors/Serotonin Norepinephrine Reuptake Inhibitors can cause serious Serotonin Syndrome. The use of ergot-type medications and Sumatriptan within 24 hours of each other should be avoided as it can cause vasospastic reactions. Sumig can cause chest discomfort and jaw or neck tightness. The prolonged use of Sumig can cause toxicity in melanin rich tissues. Sumatriptan should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Sumatriptan gets excreted in to breast milk.

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Sumatriptan is an agonist for 5-HT1D/B. Sumatriptan has weak affinity for 5-HT1A, 5-HT5A, and 5-HT7 receptors and no pharmacological activity at 5-HT2, 5-HT3, or 5-HT4 receptor sub-types or at alpha1, alpha2, or beta-adrenergic; dopamine1; dopamine2; muscarinic; or benzodiazepine receptors. The activation of 5-HT1 is believed to relieve headaches associated with migraine.

The recommended dosage of Sumatriptan for the acute treatment of migraine in adults is single doses of 25, 50, or 100 mg. The dose can be repeated after 2 hours if sufficient clinical response is not seen in patients. The maximum tolerated dose of Sumatriptan is 200mg/day.