The common side effects reported with Prilosec are hypersensitivity reactions, Chest pain or angina, tachycardia, bradycardia, palpitations, elevated blood pressure, peripheral edema, pancreatitis, anorexia, irritable colon, fecal discoloration, esophageal candidiasis, mucosal atrophy of the tongue, stomatitis, abdominal swelling, dry mouth, Psychiatric and sleep disturbances , taste perversion and urinary tract infection.

Prilosec tablet should be taken as whole tablet. Omeprazole should be taken before meals. The administration of drugs like digoxin and iron salts that require gastric pH for absorption should not be given along with Prilosec drug. The concomitant administration of Prilosec and warfarin can lead to increase in prothrombin time and bleeding disorders. Prilosec medicine should not be administered with antiretroviral drugs as it can cause development of drug resistance. The long-term use of Prilosec can cause atropic gastritis. Prilosec can be combined with amoxicillin and clarithromycin. The patient is advised to take Omeprazole along with antacids. The dose of Prilosec need not be adjusted in elderly and in patients with renal impairment. Prilosec is not recommended in infants below the age of 1. It is not advisable to consume the Omeprazole during pregnancy and lactation.

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Prilosec inhibits the acid secretion. Prilosec does not exhibit anticholinergic or H2 blocking action. At low pH Omeprazole rearranges to two charged cationic forms that reacts with SH groups of H+/K+-ATPase and inactivate it. Omeprazole irreversibly inhibits H+/K+-ATPase. The acid secretion resumes only when new enzyme molecules are synthesized.. Omeprazole also inhibits carbonic anhydrase enzyme.