The common side effects reported with Phenergan are sedation, somnolence, dizziness, blurred vision, confusion, extrapyramidal side effects, tachycardia, bradycardia, faintness, dermatitis, photosensitivity, dry mouth, nausea, vomiting, jaundice, asthma and respiratory depression.

Phenergan should not be administered in pediatric patients below the age of 2. Phenergan can cause sedation. Phenergan should not be given along with CNS depressants like alcohol as it can aggravate sedation. Phenergan should not be used along with anticholinergic drugs. Phenergan and epinephrine should be administered with caution as Phenergan reverses epinephrine vasopressor action. Phenergan and monoamine oxidase inhibitors (MAOI) should not be administered together because of extrapyramidal side effects. Promethazine should be used carefully in patients with severe cardiovascular disease or hepatic disease. Avoid alcohol while on Phenergan treatment. The patient should be advised to avoid activities that require alertness and concentration as it causes sedation. Phenergan should not be administered to pregnant women and nursing mothers. If it is an absolute must to take Phenergan during pregnancy and lactation, it should be administered under the supervision of a medical practitioner.

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Promethazine is a H1 selective antagonist. Phenergan also exhibits sedative and anti emetic properties.