The common side effects reported with Esomeprazole are enlarged abdomen, allergic reaction, asthenia, back pain, chest pain, edema, fatigue, fever, flushing, hypertension, tachycardia, bowel irregularity, constipation, dyspepsia, dysphagia, anemia, anorexia, depression, dizziness, impotence, insomnia, taste loss and abnormal vision.

Esomeprazole should not be administered with antiretroviral drugs as it can cause development of drug resistance. The administration of drugs like digoxin and iron salts that require gastric pH for absorption should not be given along with this drug. The patient should be advised to take this one hour before food. It is not advisable to consume this drug during pregnancy and lactation. It is not recommended in infants below the age of one. The dose of this drug should be adjusted in patients with severe hepatic impairment.

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Esomeprazole inhibits the acid secretion. Nexium does not exhibit anticholinergic or H2 blocking action. This drug irreversibly inhibits H+/K+-ATPase. The acid secretion resumes only when new enzyme molecules are synthesized.. It also inhibits carbonic anhydrase enzyme.