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The common side effects reported with Zyloprim are diarrhea, nausea, alkaline phosphatase increase, acute attacks of gout, rash, maculopapular rash, ecchymosis, fever, headache, necrotizing angiitis, vasculitis, hepatic necrosis, granulomatous hepatitis, hepatomegaly, hyperbilirubinemia, cholestatic jaundice, vomiting, intermittent abdominal pain, gastritis, dyspepsia, myopathy, arthralgias peripheral neuropathy, neuritis, paresthesia and somnolence.

Zyloprim can be taken after meals to minimize gastric irritation. Zyloprim inhibits the degradation of 6-mercaptopurine and azathioprine. The concomitant administration of probencid and Allopurinol should be avoided. Probencid shortens half-life of Alloxanthine (metabolite of Allopurinol) and Allopurinol prolongs the half-life of probencid. Allopurinol can potentiate warfarin and theophylline by inhibiting their metabolism. The co-administration of ampicillin and Zyloprim can cause higher incidence of skin rashes. Iron therapy is not recommended during Zyloprim treatment. Liberal fluid intake is advocated during Zyloprim therapy. Zyloprim is contraindicated in hypersensitive patients. Allopurinol is not indicated for use during pregnancy and lactation. Allopurinol should be cautiously used in elderly, children and in kidney or liver disease.