Zyloprim (Generic Allopurinol)


Allopurinol is a hypoxanthine analogue. Allopurinol inhibits xanthine oxidase enzyme and thus inhibits uric acid synthesis. Allopurinol is short acting but its major metabolite alloxanthine is a long acting non-competitive inhibitor of uric acid synthesis. Zyloprim administration can decrease the plasma concentration of uric acid and increase that of xanthine and hypoxanthine. Xanthine and hypoxanthine are water-soluble and gets eliminated in urine without precipitation and crystallization. Zyloprim is indiacted for the treatment of chronic gout. The long-term therapy of Zyloprim can cause tophi to disappear and to stop the progression of neuropathy. You can easily buy Allopurinol here.

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10 to 14 days express shipping – or 3 to 4 weeks for regular shipping. | Medshop4u Online Pharmacy.

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Side effects

The common side effects reported with Zyloprim are diarrhea, nausea, alkaline phosphatase increase, acute attacks of gout, rash, maculopapular rash, ecchymosis, fever, headache, necrotizing angiitis, vasculitis, hepatic necrosis, granulomatous hepatitis, hepatomegaly, hyperbilirubinemia, cholestatic jaundice, vomiting, intermittent abdominal pain, gastritis, dyspepsia, myopathy, arthralgias peripheral neuropathy, neuritis, paresthesia and somnolence.


Zyloprim can be taken after meals to minimize gastric irritation. Zyloprim inhibits the degradation of 6-mercaptopurine and azathioprine. The concomitant administration of probencid and Allopurinol should be avoided. Probencid shortens half-life of Alloxanthine (metabolite of Allopurinol) and Allopurinol prolongs the half-life of probencid. Allopurinol can potentiate warfarin and theophylline by inhibiting their metabolism. The co-administration of ampicillin and Zyloprim can cause higher incidence of skin rashes. Iron therapy is not recommended during Zyloprim treatment. Liberal fluid intake is advocated during Zyloprim therapy. Zyloprim is contraindicated in hypersensitive patients. Allopurinol is not indicated for use during pregnancy and lactation. Allopurinol should be cautiously used in elderly, children and in kidney or liver disease.

Additional Information


200 mg, 500mg


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