The common side effects reported with Brimonidine are allergic conjunctivitis, conjuctival hyperemia, eye pruritis, burning sensation, conjuctival folliculosis, hypertension, ocular allergic reaction, asthenia, oral dryness, blurred vision, eye discharge, eye irritation and visual disturbance.

The concomitant use of Brimonidine and CNS depressants like alcohol, opiates and sedatives should be avoided. The use of Alphagan can result in low blood pressure and reduced pulse rate. Alphagan should be used with if you are suffering from any cardiovascular disease, depression, coronary insufficiency and orthostatic hypotension. Brimonidine should not be administered in patients with hepatic or renal dysfunction. It is not advisable to use the Brimonidine during pregnancy and lactation. If it is an absolute must to use Alphagan during pregnancy and lactation, it should be administered under the supervision of a medical practitioner. Alphagan should not be used in pediatric patients below the age of 2.

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Alphagan lowers intra ocular pressure by reducing aqueous production and by increasing uveoscleral flow.