The common side effects reported with Latanoprost are Eyelash changes, eyelid skin darkening, intraocular inflammation, iris pigmentation changes, macular edema, blurred vision, burning and stinging, conjunctival hyperemia, foreign body sensation, dry eye, excessive tearing, eye pain, lid crusting, lid discomfort, lid edema, lid erythema, blurred vision, increased pigmentation of the iris, and punctate epithelial keratopathy.

Xalatan Sterile Ophthalmic Solution may increase the pigmentation of the iris due to increase in melanin pigment. Contact lenses should not be used while using Xalatan drops. The contact lens should be removed before administration of Xalatan and may be reinserted 15 minutes after administration. Latanoprost should be used with caution in pregnant women and nursing mothers. Pediatric patients should not use this medicine. It should be used with caution in patients with a history of intraocular inflammation and in patients with active intraocular inflammation.

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Latanoprost is a PGF2ά derivative. Xalatan reduces intraocular pressure by reducing aqueous production. This medicine increases the uveoscleral outflow by increasing permeability of tissues in ciliary muscle. Xalatan acts on episcleral vessels and trabecular outflow is increased.