The common side effects reported with Cyclosporine are ocular burning, conjuctival hyperemia, discharge, epiphora, eye pain, foreign body sensation, pruritis, stinging and visual disturbance.
The bottle containing Cyclosporine should be inverted before use to form an opaque, uniform white emulsion. It can be used along with artificial tears. The artificial tears should be administered 15 min after this medicine administration. The patient should be advised not to use contact lenses while administering this ophthalmic drops. The contact lens can be worn 15 minutes after it is administered. It is not advisable to use this medication during pregnancy and lactation. If it is an absolute must to use this medicine during pregnancy and lactation, it should be administered under the supervision of a medical practitioner. It is not administered in pediatric patients below the age of 16.
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How does Cyclosporine works?
Cyclosporine inhibits cell mediated immunity system. The stimulation of T-cells produces a cascade of calcium dependent events and protein kinase activation. The calcium ions binding to calmodulin activate calcineurin, which dephosphorylates regulatory proteins. This medicine enters target cells and binds to a protein called cyclophilin. This complex then binds to and inactivates calcineurin thus inhibiting antigen stimulated activation and proliferation of T-cells.