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Sodium Hyaluronate is similar to synovial fluid present in joints. Sodium Hyaluronate works by improving the joint fluid that helps the knee to move smoothly and therby reduces the pain in joints.

The common side effects reported with Hyalgan are gastrointestinal complaints, Injection site pain, knee swelling/effusion, local skin reactions like rash, ecchymosis, pruritus, headache, swelling, effusion and local skin reactions.

Strict aseptic administration technique must be followed during injection procedure. Hyaluronate should never be injected into a vein or artery. Hyalgan package should be stored at a temperature below 77° F (25°C) and should be protected from light. The joint effusion should be removed before injecting Hyalgan. The patient should be advised of transient pain and swelling of the injected joint after intra-articular injection of Hyalgan. The patient should be advised to avoid strenuous activities or prolonged weight bearing activities within 48 hours following the intra-articular injection. Sodium Hyaluronate is contraindicated in pregnancy and lactation. Sodium Hyaluronate should not be used in pediatric patients. Sodium Hyaluronate intra-articular injections are contraindiacted in patients with infections or skin diseases at the injection site. The use of Hyalgan should be done with caution patients who are allergic to avian proteins, feathers, and egg products.

The single treatment cycle consists 3 injections of Sodium Hyaluronate.