Carbidopa & Levodopa


Levodopa is inactive by itself, but is the immediate precursor of transmitter dopamine. More than 95% of oral dose of Levodopa is decarboxylated in peripheral tissues and only 1-2% crosses brain. Levodopa is taken up by dopaminergic neurons and is converted to dopamine, which is stored and released as neurotransmitter. Carbidopa is an extracerebral dopa decarboxylase inhibitor. Carbidopa does not penetrate blood brain barrier and does not inhibit the conversion of levodopa to dopamine in brain. You can buy Levodopa here

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10 to 14 days express shipping – or 3 to 4 weeks for regular shipping. | Medshop4u Online Pharmacy.

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How does Carbidopa Levodopa / Sinemet, Atamet work

The striatum of patients with Parkinson€™s disease is deficient in dopamine. Levodopa is a dopamine precursor and Carbidopa is a peripheral decarboxylase inhibitor. The combination of Carbidopa-Levodopa increases the half-life of Levodopa in the periphery and makes more of Levodopa cross blood brain barrier and reaches the site of action.


Side effects of Carbidopa Levodopa

The common side effects reported with Sinemet are chest pain, asthenia, cardiac irregularities, hypotension, orthostatic hypotension, hypertension, syncope, phlebitis, palpitation, dark saliva, gastrointestinal bleeding, duodenal ulcer, anorexia, vomiting, diarrhea, constipation, dyspepsia, dry mouth, taste alterations, agranulocytosis, anemia, thrombocytopenia, leukopenia, confusion, agitation, dizziness, somnolence, dream abnormalities, insomnia, paresthesia, headache, depression, dementia, pathological gambling and increased libido.


Guidelines before using Carbidopa Levodopa

The concomitant administration of Sinemet and antihypertensive drugs or MAO inhibitors can cause orthostatic hypotension. The administration of Dopamine D2receptor antagonists and isoniazid with Levodopa can cause a loss in its efficacy and therapeutic response. Iron salts reduce the bioavailability of Sinemet. Sinemet should be used cautiously in patients with chronic wide-angle glaucoma. It is not advisable to consume Sinemet drug during pregnancy. Carbidopa -Levodopa should not be administered to nursing mothers and patients below age of 18.


What are the common dosages of Sinemet?

Sinemet tablets are available in a 1:4 ratio of carbidopa to levodopa as well as 1:10 ratio. The recommended starting dose of Sinemet is one tablet 25-100 three times a daily.

Additional Information


10/100mg, 25/100mg, 25/250mg


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