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Naprosyn is an analgesic and antipyretic. Naprosyn is a highly potent inhibitor of prostaglandin synthesis.

The common side effects reported with Naprosyn are heartburn, abdominal pain, nausea, constipation, diarrhea, dyspepsia, stomatitis headache, dizziness, drowsiness, lightheadedness, vertigo pruritus, skin eruptions, ecchymoses, sweating, purpura, tinnitus, visual disturbances, hearing disturbances, edema, palpitations, dyspnea and thirst.

The onset of pain relief can begin within 30 minutes in patients taking Naproxen. Naprosyn decreases antihypertensive effect of Angiotensin Converting Enzyme (ACE) inhibitors and diuretics. The Concomitant administration of some antacids, cholestyramine and sucralfate delay the absorption of Naproxen. The concomitant administration of Naprosyn and lithium can cause lithium toxicity. Naprosyn should not be given along with warfarin and selective serotonin reuptake inhibitors (SSRIs) as it can cause serious GI bleeding. The use of Naprosyn with other NSAIDs can cause increased gastrointestinal toxicity. The use of Naprosyn causes an increased risk of cardiovascular thrombotic events, myocardial infarction, and stroke. Naproxen can cause serious gastrointestinal events including bleeding, ulceration, and perforation of the stomach, small intestine or large intestine. Patients should be informed of incidence of hepatotoxicity which can occur during Naproxen treatment. Naproxen can cause anemia due to fluid retention and GI blood loss. Naprosyn should be avoided in late pregnancy as it can cause the premature closure of the ductus arteriosus. The patient should be advised to avoid activities that require alertness as they may experience drowsiness, dizziness, vertigo or depression during therapy with naproxen.

The recommended dosage of Naprosyn in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis is 250-375mg twice daily. The recommended total daily dose of naproxen is 10 mg/kg given in 2 divided doses for juvenile arthritis.