Bromocriptine Mesylate


Bromocriptinea synthetic ergot derivative and is a potent dopamine agonist. Parlodel decreases prolactin release from pituitary by activating dopaminergic receptors on lactotrope cells. Bromocriptine Mesylateimproves GH release in normal individuals and decreases from pituitary tumors causing acromegaly. Parlodel causes nausea and vomiting by stimulating dopaminergic neurons in CTZ. Parlodel decreases gastric motility. Parlodel is the first line drug for hyperprolactinemia. Bromocriptineused in late cases of Parkinson€™s disease as a supplement to levodopa. Bromocriptine Mesylateimproves control and smoothens the end of dose and €œon-off€ fluctuations. Dyskinesias are less prominent with Bromocriptine Mesylatetreatment. Generic forms of this drug are now available and you can easily buy Bromocriptine Mesylateimproves here


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How does Bromocriptine / Parlodel works

Parlodel has greater action on D2 receptors. Parlodel acts as partial agonist or antagonist of D1 receptor at certain dopamine sites in brain.


Side effects of Bromocriptine / Generic of Parlode

The common side effects reported with Bromocriptine nausea, head ache, dizziness, fatigue, lightheadedness, vomiting, abdominal cramps, nasal congestion, nausea, diarrhea, drowsiness, hypotension, anorexia, dry mouth, nasal stuffiness, indigestion, dyspepsia, abnormal involuntary movements, hallucinations, confusion, “on-off” phenomenon, asthenia, abdominal discomfort, visual disturbance, ataxia, insomnia, depression, hypotension, shortness of breath and vertigo.


Guidelines before using Bromocriptine / Parlodel

Parlodel causes hypotension due to central suppression of postural reflexes and weak peripheral ά blockade. Parlodel is not recommended for use in children below the age of 8. Bromocriptine contraindicated in patients with renal or hepatic disease. Bromocriptine should be used with caution in patients with a history of psychosis and cardiovascular disease. Parlodel should not be administered to patients having galactose intolerance, the severe lactase deficiency or glucose-galactose malabsorption. Bromocriptine cause cold-sensitive digital vasospasm in acromegaly patients. The use of Bromocriptine in higher doses can cause confusion and mental disturbances. Parlodel should be administered with caution in patients with myocardial infarction. It is not advisable to consume the Parlodel during pregnancy and lactation.


What are the common dosages of Parlodel?

The recommended dosage of Parlodel is 2.5-15mg daily. The dose of Parlodel in children is 2.5-10mg daily.



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