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Memantine HCI is an N-methyl-D-aspartate (NMDA) antagonist. The symptoms of Alzheimer`s disease is due to persistent activation of N-methyl-D-aspartate (NMDA) receptors by excitatory amino acid glutamate. Namenda binds to N-methyl-D-aspartate (NMDA) cation channel. Memantine HCI also blocks GABA transmission in brain.

The common side effects reported with Namenda are fatigue, pain, hypertension, dizziness, headache, constipation, vomiting, back pain, confusion, somnolence, hallucination, coughing and dyspnea.

Memantine HCI can be taken without regard of food. Namenda should be administered with caution with other N-methyl-D-aspartate (NMDA) antagonists. Namenda should be used cautiously in patients with genitourinary diseases as increased urine pH can decrease the elimination of Memantine HCI. The dose of Namenda need not be adjusted in patients with mild to moderate renal or hepatic impairment. Namenda should be used in pregnancy only if clearly indicated. Memantine HCI should not be given to nursing mothers as it can get excreted through breast milk. Memantine HCI is not administered in pediatric patients. Memantine HCI can cause dizziness. Hence patients should be advised to avoid activities that require alertness.

The recommended starting dose of Namenda is 5 mg once daily. The recommended maintenance dose of Memantine HCI for dementia is 20mg/day. The increments in dose should be done in an interval of 1 week. In patients with severe renal impairment the dose of Namenda should be 5mg once daily.