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Celebrex acts by inhibition of prostaglandin synthesis via inhibition of cyclooxygenase-2 (COX-2).

The common side effects reported with Celebrex are constipation, diverticulitis, dysphagia, esophagitis, gastritis, gastroenteritis, gastroesophageal reflux, hemorrhoids, hiatal hernia, melena, dry mouth, stomatitis, tenesmus, vomiting aggravated hypertension, angina pectoris, coronary artery disorder hypertonia, hypoesthesia, migraine, palpitation, tachycardia, arthralgia, arthrosis, myalgia, synovitis, tendinitis bronchitis and bronchospasm.

Celecoxib can be taken without regard of food. The concomitant administration of Celecoxib and warfarin should be done cautiously as it can cause increased risk of bleeding. The concomitant administration of aspirin with Celebrex increases the rate of gastrointestinal ulceration. Celebrex decreases antihypertensive effect of Angiotensin Converting Enzyme (ACE) inhibitors and angiotensin II antagonists. Celebrex should not be administered with any dose of a non-aspirin NSAID due to increased risk of adverse reactions. The chronic use of Celebrex causes an increased risk of cardiovascular thrombotic events, myocardial infarction, and stroke. Celebrex should be used with caution in patients with hypertension. Celebrex can cause fluid retention and edema. It can also cause serious gastrointestinal events including bleeding, ulceration, and perforation of the stomach, small intestine or large intestine. Celebrex should be avoided in late pregnancy as it causes premature closure of the ductus arteriosus. Patients should be informed of the warning signs and symptoms of hepatotoxicity, which can occur during Celebrex treatment. The long-term administration of Celebrex can cause renal injury. Celebrex is not recommended for use by nursing mothers.

The recommended starting dosage of Celecoxib in Osteoarthritis is 200 mg per day administered as a single dose or as 100 mg twice daily. In Rheumatoid Arthritis the dose of Celecoxib is 100 to 200 mg twice daily. In Juvenile Rheumatoid Arthritis the dose of Celebrex is 50 to 100mg twice daily. The recommended dose of Celebrex in Ankylosing Spondylitis is 200 mg daily in single or divided doses. The recommended dose of Celebrex in the management of acute pain is 400mg on first day, followed by 200mg daily.