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Ibuprofen inhibits prostaglandin synthesis. Nurofen inhibits platelet aggregation and prolong bleeding time.

The common side effects reported with Ibuprofen are nausea, epigasric pain, heart burn, diarrhea, abdominal distress, vomiting, constipation, indigestion, abdominal cramps, gastric or duodenal ulcer, gastritis, hepatitis, jaundice, depression, insomnia, confusion, emotional liability, somnolence, dizziness, headache, nervousness, rash, hearing loss, amblyopia, tinnitus, edema and fluid retention.

Ibuprofen decreases antihypertensive effect of Angiotensin Converting Enzyme inhibitors. The concomitant administration of this medicine and lithium can cause lithium toxicity. The concomitant administration of this medicine and warfarin type anticoagulants can cause with fatal gastrointestinal bleeding. It can reduce the diuretic and antihypertensive effects of diuretics. The use of this medicine with other NSAIDs can cause increased gastrointestinal toxicity. The use of this drug causes an increased risk of cardiovascular thrombotic events, myocardial infarction, and stroke. It can cause serious gastrointestinal events including bleeding, ulceration, and perforation of the stomach, small intestine or large intestine. Patients should be informed of incidence of hepatotoxicity, which can occur during treatment. It is not recommended for pediatric patients. This can cause anemia due to fluid retention and GI blood loss. This should be avoided in late pregnancy as it can cause the premature closure of the ductus arteriosus. It is not recommended for nursing mothers.