Isosorbide Dinitrate


The dilator effect on large coronary arteries is the principal action of Isosorbide Dinitrate benefiting angina by counteracting coronary spasm. Isosorbide Dinitrate gets rapidly denitrated enzymatically in smooth muscles to release free radical nitric oxide. The nitric oxide free radicals activate cytosolic guanylyl cyclase and causes dephosphorylation of myosin light chain kinase. The reduced availability of phosphorylated myosin light chain kinase interferes with the activation of myosin. Myosin fails to interact with actin and cause relaxation. Generic forms of this drug are also available now and you can easily


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How does Isosorbide Dinitrate

The main action of Isosorbide Dinitrate is relaxation of vascular smooth muscle and dilatation of peripheral arteries and veins. The dilatation of the veins promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing preload. Arteriolar relaxations reduce systemic vascular resistance, systolic arterial pressure, and mean arterial pressure (after load). Isordil causes direct smooth muscle relaxation. Isordil relaxes bigger conducting coronary arteries.

Side effects of Isosorbide Dinitrate

The common side effects reported with Isordil are recurrent headache, transient episodes of lightheadedness, hypotension syncope, crescendo, angina, and rebound hypertension.

Guidelines before using Isosorbide Dinitrate

Isosorbide Dinitrate can cause hypotension in upright posture. Hence Isosorbide Dinitrate should be used carefully in patients with volume depletion or who are already hypotensive. It is not advisable to consume the Isordil during pregnancy. If it is an absolute must to take Isordil during pregnancy, it should be administered under the supervision of a medical practitioner. Isordil is not administered to nursing mothers as it gets excreted in breast milk. The use of Isosorbide Dinitrate is contraindicated in pediatric patients.

What are the common dosages of Isosorbide Dinitrat

The recommended starting dosage of Isordil in adults is 5 to 20 mg two or three times daily. The maintenance dose of Isordil is 10 to 40mg two or three times daily. To minimize tolerance dose-free interval of at least 14 hours is recommended daily.


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