Meloxicam is a preferential COX-2 inhibitor. This medicine has a COX-2:COX-1 selectivity ratio of 10-14. It causes milder gastric side effects though the long-term use of Mobic can cause bleeding and perforation.


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How does Meloxicam / Generic Mobic, Metacan works

Mobic inhibits prostaglandin synthetase (cyclo-oxygenase) enzyme. The inhibition of platelet TXA2 occurs at therapeutic doses of Meloxicam.

Side effects of Meloxicam / Generic Mobic, Metacan

The common side effects reported with Mobic are allergic reaction, anaphylactoid reactions, angina pectoris, cardiac failure, hypertension, hypotension, myocardial infarction, convulsions, paresthesia, tremor, vertigo, colitis, dry mouth, duodenal ulcer, eructation, esophagitis, gastric ulcer, gastritis, gastroesophageal reflux, gastrointestinal hemorrhage, hematemesis, hemorrhagic duodenal ulcer, hemorrhagic gastric ulcer, intestinal perforation, palpitation, tachycardia, abnormal dreaming, anxiety, appetite increased, confusion, depression, nervousness and somnolence.

Guidelines before using Meloxicam Generic Mobic,

Meloxicam decreases antihypertensive effect of Angiotensin Converting Enzyme (ACE) inhibitors. This medicine is not a substitute for aspirin for cardiovascular prophylaxis. The concomitant administration of Mobic and lithium can cause lithium toxicity. The concomitant administration of this medicine and warfarin type anticoagulants can cause with fatal gastrointestinal bleeding. It should be used with caution in patients with impaired renal function. It should be used carefully in patients suffering from dehydration. The patient should be re-hydrated before initiation of therapy with this medicine. Mobic can reduce the diuretic and antihypertensive effects of loop, and thiazide diuretics. The use of this medicine with low dose aspirin can cause increased gastrointestinal ulceration. The use of Mobic causes an increased risk of cardiovascular thrombotic events, myocardial infarction, and stroke. It can cause serious gastrointestinal events including bleeding, ulceration, and perforation of the stomach, small intestine or large intestine. Patients should be informed of incidence of hepatotoxicity, which can occur during Mobic treatment. It is not used as an alternative to corticosteroids or to treat corticosteroid insufficiency. It can cause anemia due to fluid retention and GI blood loss. Mobic can cause serious skin side effects such as exfoliative dermatitis.

What are the common dosages of Meloxicam

The recommended starting dosage of Melexicam in osteoarthritis is 7.5mg once daily. The dose can be increased to 15mg once daily for additional benefits.


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