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Pramipexole is selective D2/D3 receptor agonist with negligible affinity for D1 and nondopaminergic receptors. The exact mechanism of action of Mirapex to treat Parkinson€™s disease is unknown. It is believed that the drug stimulates the dopamine receptors in the striatum, which is thought to be contributing to treating Parkinson€™s disease.

The common side effects reported with Mirapex are asthenia, general edema, malaise, fever, nausea, constipation, anorexia, dysphagia, peripheral edema, decreased weight, dizziness, somnolence, insomnia, hallucination, confusion, amnesia, hypesthesia, dystonia, akathisia, thinking abnormalities, decreased libido, vision abnormalities and impotence.

The dose of Pramipexole should be reduced and the period of the titration of dose should be increased in patients with renal impairment. Mirapex can exacerbate preexisting dyskinesia when given along with levodopa. Mirapex should be taken along with food to reduce nausea. It is not advisable to consume the Pramipexole drug during pregnancy. If it is an absolute must to take Pramipexole during pregnancy, it should be administered under the supervision of a medical practitioner. Nursing mothers should not use Pramipexole. The use of Pramipexole is contraindicated in children.

The recommended starting dosage of Mirapex for Parkinson€™s disease is 0.375 mg/day given in three divided doses. The dose of Mirapex should be increased only in a period of 5-7 days. The maximum dose of Mirapex is 4.5mg/day taken in three divided doses. The dose of Pramipexole in restless legs syndrome is 0.125 mg taken once daily 2-3 hours before bedtime.