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The oxidation of dopamine and environmental toxins in the striatum by MAO to free radicals cause Parkinson€™ disease. Eldepryl delays the progression of the disorder.

The common side effects reported with Eldepryl are increased tremor, chorea, loss of balance, restlessness, blepharospasm, increased bradykinesia, tardive dyskinesia, dystonic symptoms, dyskinesia, involuntary movements, freezing, festination, hallucinations, dizziness, confusion, anxiety, depression, drowsiness, behavior/mood change, headache, back pain, leg pain, tinnitus, migraine, supraorbital pain, throat burning, orthostatic hypotension, hypertension, arrhythmia, palpitations, new or increased angina pectoris, nausea/vomiting, constipation, weight loss, anorexia, poor appetite, dysphagia and diarrhea.

The concomitant administration of Selegiline and meperidine can cause stupor, muscular rigidity, severe agitation, and elevated temperature. It is not advisable to consume the Eldepryl during pregnancy. If it is an absolute must to take Eldepryl during pregnancy, it should be administered under the supervision of a medical practitioner. Eldepryl should be used with caution in nursing mothers.

The recommended starting dose of Eldepryl is 10 mg per day administered as divided doses of 5 mg each taken at breakfast and lunch. Eldepryl is used along with levodopa/ carbidopa.